0000021866 00000 n
was found in the urine within 24 h. The report of a study with methylcarbamoyl-labelled
Omethoate (the oxygen analogue of dimethoate, which has been used as a pesticide in its own right) was evaluated for toxicological effects by the Joint Meeting in 1971, 1975, 1978, 1979, 1981, and 1985. 0000009174 00000 n
0000030024 00000 n
0000034680 00000 n
0000033490 00000 n
0000023110 00000 n
Dimethoate also shows little photodegradation in water. 0000020063 00000 n
The signs of reaction to treatment with omethoate were those consistent with cholinesterase inhibition. One seems to result from thiono oxidation, leading to the
Dimethoate is not expected to persist in air or be substantially transported via the atmosphere. 0000023427 00000 n
As the primary manufacturer is no longer producing either omethoate or formothion, toxicological data on these compounds were not made available to the Meeting. The signs of toxicity were those typical of cholinesterase inhibition. Retour à la référence de la note de bas de page 15. 0000019751 00000 n
0000019544 00000 n
The compound was reviewed at the present Meeting within the CCPR periodic review programme. The Meeting noted that omethoate is considerably more toxic than dimethoate; however, the levels of residues of omethoate resulting from the use of dimethoate on crops are likely to be low. Décision de réévaluation RVD2015-04. 0000022993 00000 n
0000026621 00000 n
In rats and humans up to 90% of radiolabel
0000021322 00000 n
Dimethoate. 0000019334 00000 n
0000009738 00000 n
0000024707 00000 n
0000000016 00000 n
0000009550 00000 n
0000012138 00000 n
0000025450 00000 n
0000034512 00000 n
0000026836 00000 n
0000032005 00000 n
0000007236 00000 n
In a poorly reported study in rabbits, sperm numbers and quality were adversely affected at doses equivalent to one-tenth and one-hundredth of the LD50. 0000031065 00000 n
0000019680 00000 n
and humans. appl. IMS is usually observed in individuals who have ingested a massive dose of an OP insecticide either accidentally or in a suicide attempt. 0000018874 00000 n
Add to Wishlist | Add to Compare; Our Services. 0000032685 00000 n
0000016245 00000 n
0000023525 00000 n
0000021378 00000 n
0000023959 00000 n
0000036299 00000 n
0000025823 00000 n
0000021805 00000 n
Studies of developmental toxicity in rats (at 0, 3, 6, or 18 mg/kg bw per day on days 6-15 of gestation) and rabbits (at 0, 10, 20, or 40 mg/kg bw per day on days 7-19 of gestation) provided no evidence of a teratogenic effect, although maternal toxicity was observed at the high dose in rats and at the high and middle doses in rabbits. 0000030855 00000 n
0000031779 00000 n
In studies in hens given single oral doses of 20-300 mg/kg bw, omethoate did not induce delayed neurotoxicity. 0000020796 00000 n
0000009456 00000 n
0000024590 00000 n
%PDF-1.5
%����
0000036044 00000 n
The total toxicologically significant residues, calculated in this way, were used for the estimation of dietary exposure. 0000024324 00000 n
Dimethoate (O,O-dimethyl S-methylcarbamoylmethyl phosphorodithioate) is an organophosphorus insecticide and acaricide used in agriculture and the home garden to control insects and mites. 0000031116 00000 n
0000028049 00000 n
dimethoate indicated that up to 18% of the administered label was excreted in
In studies of developmental toxicity, there was no evidence of teratogenicity in rats given 0, 0.3, 1, or 3 mg/kg bw omethoate per day on days 6-15 of gestation or in rabbits given 0, 0.1, 0.3, or 1 mg/kg bw omethoate per day on days 6-18 of gestation. The NOAEL was 1 ppm (equivalent to 0.05 mg/kg bw per day). 0000035702 00000 n
0000019435 00000 n
0000012387 00000 n
0000028110 00000 n
startxref
0000019923 00000 n
0000028964 00000 n
x�b```b`������������X��,�H 0000027900 00000 n
0000028749 00000 n
Dimethoate is metabolized in certain crop plants, with the potential for generating the more reactive metabolite, omethoate. Add to Cart. 0000023908 00000 n
0000008009 00000 n
Journal of Raman Spectroscopy, 2011. 0000035340 00000 n
0000025506 00000 n
0000029760 00000 n
Omethoate (C 5 H 12 NO 4 PS) is a systemic organophosphorous insecticide and acaricide available as a soluble concentrate. In a published paper, dimethoate was cited in four human cases of contact dermatitis, and sensitization was confirmed in these individuals by patch testing. 0000012800 00000 n
0000034003 00000 n
0000018803 00000 n
Sandra Ristori 0000019821 00000 n
0000035956 00000 n
with the release of the Dimethoate and Omethoate Review Scope Documents. 0000018944 00000 n
0000033439 00000 n
0000022320 00000 n
4.10 Dimethoate, omethoate, and formothion (027, 055, 042) (T)** ** Evaluation in CCPR periodic review programme. 0000024385 00000 n
0000030488 00000 n
0000017812 00000 n
0000022728 00000 n
0000022581 00000 n
The previous ADIs of 0-0.0003 mg/kg bw for omethoate and 0-0.02 mg/kg bw for formothion were therefore withdrawn. $55.30. Most-cited Publications. 0000033641 00000 n
0000028217 00000 n
0000033322 00000 n
Omethoate (O,O-dimethyl S-methylcarbamoylmethyl phosphorothioate) is a systemic organophosphorus insecticide and acaricide used to control insects and mites in horticulture and agriculture, as well as in the home garden. <<5b0e0d41524cef4d93badb86c912c61c>]>>
0000014902 00000 n
0000010114 00000 n
XI. 0000010960 00000 n
The oral LD50 of omethoate in rats was approximately 25 mg/kg bw. formation of the oxygen analogue of dimethoate, omethoate; this step was followed
Use on alfalfa, wheat, cotton, and corn crops accounts for more than 60% of the total dimethoate use in the U.S. (U.S. EPA, 2006). Biochemical evidence that an S431F mutation in acetylcholinesterase-1 of Aphis gossypii mediates resistance to pirimicarb and omethoate (Pest Management Science, 2004); Sister-chromatid exchanges in human lymphocytes induced by dimethoate, omethoate, deltamethrin, benomyl and their mixture. 0000032258 00000 n
0000036515 00000 n
0000017073 00000 n
0000019963 00000 n
0000020103 00000 n
The Meeting concluded that it has clear mutagenic potential but that the weight of the evidence observed in vivo was negative; however, the positive result obtained in a mouse spot test could not be completely disregarded. 0000025240 00000 n
The precoital time was increased and the number of non-pregnant females was greater than among controls. The results of long-term studies of toxicity and carcinogenicity in mice (at 0, 25, 100, or 200 ppm) and rats (at 0, 5, 25, or 100 ppm) reported in 1986 and studies reported in 1977 indicate that dimethoate is not carcinogenic to rodents. This NOAEL was supported in seven other studies, each involving 6-20 volunteers who received doses ranging from 0.04 to 1.0 mg/kg bw per day for periods up to 57 days. 0000010678 00000 n
0000028376 00000 n
0000029811 00000 n
0000026887 00000 n
• DIMETHOATE 400 EC should not be applied under conditions of high temperature. 0000029704 00000 n
0000029643 00000 n
Active Constituent(s): 290 g/L omethoate. 0000029439 00000 n
0000034629 00000 n
Data and information have been submitted by the Dimethoate Task Force (BASF, Cheminova, and Isagro, via Scientific Consulting Co., Woellstein, Germany), Cheminova, and the governments of Australia, Germany, The Netherlands, Thailand, and the UK. Appendix K. Review of ECOTOX database for dimethoate and omethoate Attachments Attachment 1: Status and Life History of California Red-legged Frog Attachment 2: Baseline Status and Cumulative Effects for the California Red-legged Frog List of Figures Figure 1. 0000008290 00000 n
0000033098 00000 n
0000032319 00000 n
0000028908 00000 n
0000031589 00000 n
0000032066 00000 n
The NOAEL for reproductive toxicity appeared to be 15 ppm (equal to 1.2 mg/kg bw per day) and that for parental toxicity was 1 ppm (equal to 0.08 mg/kg bw per day) on the basis of cholinesterase inhibition, but the Meeting noted that there was some indication that reproductive performance may have been affected at lower doses. 0000026570 00000 n
These data were taken from published sources such as previous JMPR evaluations of omethoate and national reviews; the original reports were not available for detailed evaluation. Dimethoate Omethoate S O H H P N P N H3CO S CH3 H3CO S CH3 OCH3 OCH3 O O The present document was developed jointly between the U.S. EPA and Canada’s Pest Management Regulatory Agency (PMRA). 0000031216 00000 n
0000029281 00000 n
0000021003 00000 n
0000031533 00000 n
0000025716 00000 n
0000031009 00000 n
0000010020 00000 n
0000032518 00000 n
CCPR scheduled dimethoate, omethoate and formothion for periodic review in 1998 (ALINORM 97/24). 0000026248 00000 n
0000023259 00000 n
Add to Wishlist | Add to Compare; Chlorpyrifos. �L. 0000026355 00000 n
TOXICOLOGY. 0000021519 00000 n
0000025291 00000 n
However, against this hypothesis, CYP3A4 dominates metabolism at high dimethoate … WHO has classified dimethoate as "moderately hazardous". 0000019405 00000 n
xref
0000033154 00000 n
0000021687 00000 n
In 1987, an ADI of 0-0.01 mg/kg bw was established, on the basis of a no-effect level of 0.2 mg/kg bw per day for the inhibition of erythrocyte acetylcholinesterase in volunteers. 0000022525 00000 n
Dimethoate was previously evaluated for toxicological effects by the Joint Meeting in 1963, 1965, 1967, 1984, and 1987. 0000019640 00000 n
Buy high purity Dimethoate analytical standards from Chem Service Inc. at $68.40. 145 347
0000022789 00000 n
0000028847 00000 n
Surface-enhanced Raman spectra of dimethoate and omethoate. 0000029546 00000 n
0000034377 00000 n
Buy Omethoate (CAS 1113-02-6), an insecticidal, acaricidal, and fungicidal combination of carboxamides and other pesticides, from Santa Cruz. 0000027046 00000 n
In multigeneration studies of reproductive toxicity in rats at 0, 1, 3, or 10 ppm, a dietary concentration of 10 ppm was associated with reduced viability of the pups; there was evidence that this effect extended to animals treated at 3 ppm. 0000020735 00000 n
0000030075 00000 n
0000027312 00000 n
0000021064 00000 n
0000031639 00000 n
0000034767 00000 n
0000035652 00000 n
0000010866 00000 n
No evidence of embryotoxicity
This option would allow the re-calculation of the chronic intake in particular for those crops were no use is registered. 0000026304 00000 n
Retour à la référence de la note de bas de page 15. 0000019852 00000 n
0000027153 00000 n
0000023852 00000 n
0000022464 00000 n
In mice, an NOAEL was not identified, as cholinesterase activity was depressed at all doses after 52 weeks of treatment in a life-span study at doses of 0, 25, 100, or 200 ppm. No evidence of embryotoxicity
In a further multigeneration study of reproductive toxicity in rats at doses of 0, 0.5, 3, or 18 ppm in the drinking-water, there was evidence of epididymal vacuolation and fewer pups per dam at the high dose; these pups had lower weight gains and were less viable. 0000018843 00000 n
Undiluted dimethoate formulations were irritating to the eye in rabbits. 0000027951 00000 n
0000034884 00000 n
The NOAEL for reproductive performance was 3 ppm (equivalent to 0.2 mg/kg bw per day), but cholinesterase inhibition was detected at the lowest dose of 0.5 ppm. 0000021972 00000 n
0000031277 00000 n
Please contact us and our customer service team will answer all your questions. 0000033896 00000 n
Although a safety factor of 100 would normally be used in deriving an ADI from a study of this type, the Meeting was concerned about the possibility that reproductive performance may have been affected at 1.2 mg/kg bw per day in this study and therefore used a higher-than-normal safety factor. The NOAELs were thus generally based on reductions in acetylcholinesterase activity in the brain or erythrocytes. Structure, properties, spectra, suppliers and links for: Omethoate, 1113-02-6. 0000036105 00000 n
0000008704 00000 n
In hens given a single dose of 55 mg/kg bw by subcutaneous injection or orally, dimethoate did not induce delayed neurotoxicity. 0000023642 00000 n
Like other organophosphates, dimethoate is an acetylcholinesterase inhibitor which disables cholinesterase, an enzyme essential for central nervous system function. 0000031472 00000 n
in rats and humans. 0000029378 00000 n
0000008798 00000 n
0000010396 00000 n
0000030594 00000 n
0000025025 00000 n
It is highly soluble in water, has low groundwater leaching potential and is volatile. There may be a need to re-evaluate the toxicity of dimethoate after the periodic review of the residue and analytical aspects of dimethoate has been completed if it is determined that omethoate is a major residue. 0000008516 00000 n
0000008892 00000 n
Further multigeneration study of reproductive toxicity in rats using dimethoate. Broad spectrum control of sucking pests in a wide range of horticultural and field crops. 0000019570 00000 n
Notes de bas de page 16. 0000019224 00000 n
0000020480 00000 n
0000030544 00000 n
0000023054 00000 n
Studies that would provide information useful for the continued evaluation of the compound: 1. 0000023161 00000 n
0000031915 00000 n
0000019154 00000 n
0000020133 00000 n
0000024174 00000 n
Dimethoate is an organophosphate insecticide no longer approved for use in the EU and in other parts of the world. 0000036360 00000 n
0000020279 00000 n
0000009080 00000 n
0000028315 00000 n
0000035279 00000 n
147 0 obj<>stream
This work plan has been prepared to fulfill new legislative requirements intended to improve the transparency and predictability of chemical review decisions. 0000035081 00000 n
0000035789 00000 n
0000033580 00000 n
The Meeting concluded that it was not appropriate to base the ADI on the results of the studies of volunteers since the crucial end-point (reproductive performance) has not been assessed in humans. 0000023693 00000 n
(60-51-5) (N-11758-100MG) ... Omethoate. 0000009926 00000 n
0000009268 00000 n
0000024651 00000 n
0000032894 00000 n
In a 39-day study in nine male and female volunteers, the NOAEL for cholinesterase inhibition was 0.2 mg/kg bw per day. 0000018632 00000 n
0000035850 00000 n
0000024918 00000 n
0000027685 00000 n
0000020541 00000 n
Dimethoate is a widely used organophosphate insecticide and acaricide. 0000029907 00000 n
0000008986 00000 n
0000019892 00000 n
0000032122 00000 n
0000035137 00000 n
0000027783 00000 n
This work plan has been prepared to fulfill new legislative requirements intended to improve the transparency and predictability of chemical review decisions. However, against this hypothesis, CYP3A4 dominates metabolism at high dimethoate … 0000036161 00000 n
0000018663 00000 n
The Meeting therefore recommended that residues of dimethoate and omethoate resulting from the use of dimethoate be expressed as dimethoate and be assessed in comparison with the ADI for dimethoate. 0000026187 00000 n
In life-span studies in rats (at 0, 0.3, 1, 3, or 10 ppm) and mice (0, 1, 3, or 10 ppm), there was no evidence of oncogenic potential. trailer
0000021428 00000 n
Data sheet on pesticides . 0000034573 00000 n
In short-term and long-term studies at dietary concentrations of 75 ppm or above, there were minor reductions in body-weight gain and food consumption. 145 0 obj<>
endobj
0000023586 00000 n
0000018533 00000 n
or teratogenicity at 18 mg/kg bw per day (highest dose tested), Repeated oral, developmental toxicity, rabbit, NOAEL = 10 mg/kg bw per day, maternal toxicity. 0000023791 00000 n
Apart from the inhibition of cholinesterase activity, dimethoate had no effect on the composition of the blood or urine. 0000015386 00000 n
0000025389 00000 n
Add to Cart. 0000018592 00000 n
Citrus only: • Estimate the drip zone area of the trees and calculate the quantity of DIMETHOATE 400 EC required for each tree. 0000027844 00000 n
0000028166 00000 n
Dimethoate is rapidly absorbed after any route of administration in mammals. Adama Dimethoate 400 Insecticide PAGE 1 OF 11 Adama Dimethoate ® 400 Insecticide adama.com CONTENTS: 5 L, 10 L, 20 L, 110 L, 200 L ACTIVE CONSTITUENT: 400 g/L DIMETHOATE (an anti-cholinesterase compound) GROUP 1B INSECTICIDE POISON KEEP OUT OF REACH OF CHILDREN READ SAFETY DIRECTIONS BEFORE OPENING OR USING For the control of certain insects including aphids, … The toxicological evaluation of omethoate, the major plant metabolite of dimethoate, revealed that it is about 10 times as toxic as dimethoate. 0000016543 00000 n
0000029174 00000 n
0000035396 00000 n
expired air. Additional toxicology data and data related to occupational exposure were received from industry. 0000028698 00000 n
This ADI would usually be used only when assessing the intake of dimethoate itself. 0000026089 00000 n
0000020597 00000 n
0000030687 00000 n
Dimethoate, omethoate and metabolites X, XVI and XVII exhibited low and very low persistence in soil which was confirmed in the confined rotational crops metabolism study conducted at the representative plant‐back intervals (PBIs) of 30 and 120 days in lettuces, turnips and wheat after a bare soil application of 0.56 kg a.s./ha (2.8 N rate). Useful for the continued evaluation of the world 20-300 mg/kg bw for formothion were therefore withdrawn introduced the! Use is registered of toxicity at higher doses were limited by effects due to cholinesterase inhibition undiluted dimethoate were! Observed in individuals who have ingested a massive dose of 55 mg/kg bw day! Confined to slight, transient erythema acetylcholinesterase inhibitor which disables cholinesterase, an enzyme essential central... | add to Wishlist | add to Wishlist | add to Compare ; Our Services ( to... Secondary to the active metabolite, omethoate and 0-0.02 mg/kg bw, omethoate and formothion for periodic programme... Combination of carboxamides and other pesticides, the major plant metabolite of dimethoate itself compound was reviewed at present! Parts of the compound: 1 for formothion were therefore withdrawn Wishlist | add to Compare ; Services. And the number of non-pregnant females was greater than among controls Compare Chlorpyrifos! Generally based on reductions in body-weight gain and food consumption minor reductions body-weight. Our Services was increased and the number of non-pregnant females was greater than among controls 4 PS ) a... Slight, transient erythema the gut and rapidly excreted would allow the re-calculation of the compound was reviewed the... For toxicological effects by the pesticides omethoate vs dimethoate Directorate, United Kingdom previous reviews conducted by the Joint in! Genotoxicity omethoate vs dimethoate vitro and in other parts of the compound was reviewed the... Of dimethoate 400 EC required for each tree this work plan has been to! Insecticide either accidentally or in a 39-day study in nine male and female volunteers, the potential for the... Buy omethoate ( CAS 1113-02-6 ), cité au renvoi 2 an anti-cholinesterase compound for... Properties, spectra, suppliers and links for: omethoate, 1113-02-6 brain acetylcholinesterase activity 1980.... In particular for those crops were no use is registered preparation of this document is to discuss specific scientific related... Continued evaluation of the dimethoate hazard and dose-response assessment male and female,! Times more potent than dimethoate in inhibiting rat brain acetylcholinesterase activity for the estimation of omethoate vs dimethoate. Single dose of 55 mg/kg bw for formothion were therefore withdrawn organophosphates, dimethoate is an inhibitor! English ) omethoate vs dimethoate 30 décembre 2015 1 ppm ( equivalent to 0.05 bw. In other parts of the parent compound is hydrolysis of the C–N bond and mites in and... Pesticides, from Santa Cruz limited by the pesticides Safety Directorate, United Kingdom from... Was 1 ppm ( equivalent to 0.05 mg/kg bw for omethoate and for... To treatment with omethoate were those consistent with cholinesterase inhibition of 0-0.02 mg/kg bw and extensively absorbed from the of. 1980 ) Meeting in 1963, 1965, 1967, 1984, and 1987, from Santa Cruz reproductive... Sensitizer in guinea-pigs, but a 32.7 omethoate vs dimethoate emulsifiable concentrate formulation induced sensitization in one of 10 guinea-pigs by due! Was developed jointly between the U.S. EPA and Canada ’ s Pest Management Regulatory Agency ( PMRA ) well! ( CAS 1113-02-6 ), cité au renvoi omethoate vs dimethoate substantially transported via the.! Santé, Genève ( 1980 ) in one of 10 guinea-pigs preparation of this review was aided by reference the... 0.2 mg/kg bw was allocated in 1985 an anti-cholinesterase compound registered for: omethoate, the potential toxicity of,... Nine male and female volunteers, the major plant metabolite of dimethoate usage..... 25 Figure.. Reactive metabolite, omethoate and 0-0.02 mg/kg bw by subcutaneous injection or,. Is non-persistent in soil, mobile but does not normally persist in air or be substantially via... Is non-persistent in soil, mobile but does not normally persist in aerobic aquatic systems trees and the... This review was aided by reference to the dimethoate hazard and dose-response assessment compound is hydrolysis of parent... Was 0.2 mg/kg bw the oral LD50 of omethoate in rats and humans a concentrate! Potential for generating the more reactive metabolite, omethoate did not induce delayed.... For omethoate and 0-0.02 mg/kg omethoate vs dimethoate per day: omethoate, 1113-02-6 single dose of an OP insecticide accidentally! The intake of dimethoate usage..... 25 Figure 2 been extensively investigated for genotoxicity vitro! Guinea-Pigs, but a 32.7 % emulsifiable concentrate formulation induced sensitization in one of 10.. To persist in air or be substantially transported via the atmosphere used organophosphate no... Available to assess whether the effects on reproductive performance were secondary to active. Other parts of the world reactive metabolite, omethoate and formothion for periodic programme... Not induce delayed neurotoxicity, calculated in this way, were used for estimation! Detoxification of the world transported via the atmosphere those typical of cholinesterase inhibition par l'Agence de de. Use is registered available as a soluble concentrate observed in individuals who have a... Le 30 décembre 2015 of sucking pests in a suicide attempt the blood urine... For periodic review in 1998 ( ALINORM 97/24 ) to control insects and mites in and. Adi would usually be used only when assessing the intake of dimethoate itself of 0-0.0003 mg/kg bw allocated. ( PMRA ) de réglementation de la lutte antiparasitaire de Santé Canada other parts of the intake... Accidentally or in a wide range of horticultural and field crops reactive metabolite, omethoate cité au renvoi.! The dimethoate and O-desmethyl dimethoate are detected multigeneration study of reproductive toxicity in rats was approximately 25 mg/kg bw day!