Cymbopogon essential oils and constituents present therein e.g. Sign up here as a reviewer to help fast-track new submissions. Currently, EGFR-TKIs significantly extend the progression-free survival of patients with NSCLC. The inlet temperature was 240°C and the oven temperature program was as follows: 60°C to 220°C at 4°C/min and then at 20°C/min to 240°C with an interphase temperature of 280°C. Aromatherapy: do essential oils really work? Myrcene was the second abundant component in the C. citratus essential oils. After 48 h, the culture medium was removed and the cells were washed twice with PBS. Essential oil analysis: GC/MS analysis was performed using an Agilent GC7890A apparatus coupled to a mass selective detector (Agilent 5976C). The MS interface temperature was 270°C, MS mode, EI detector voltage 1300 V, and mass range 40–400 Da at 1.0 scan/s. Lemongrass essential oil may ease stomachaches, nausea, diarrhea, and ulcers. Recently, nearly four dozen different histopathological variants of lung carcinoma have been recognized. Widely available online, lemongrass essential oil is sold in many natural-foods stores and in stores specializing in self-care products. For the study, participants used as a shampoo and cream containing lemongrass essential oil three times a week or a cream containing 2% ketoconazole (a medication used to treat fungal infections) twice a day. The citral content was higher in the essential oil obtained from the leaf than in that from the culm of lemongrass in all regions. FACS analysis using Annexin-V-FITC and propidium iodide staining was used to assess the effect of HLL on apoptosis in A549 cells. Parasitol.Res 2009;105(6):1489-1496. The essential oil was obtained by hydro-distillation of the leaves dried by every treatment, and was analyzed by capillary GC and GC/mass instruments. The results showed that citral is the major component accounting for 61.20%–76.46% of the essential oils. Cell cycle analysis was measured by a Novocyte 2000 flow cytometer (ACEA Biosciences Inc, USA) with 10,000 events per sample and analysis by NovoExpress software. Helium was the carrier gas with a flow rate of 1.0 mL/min. Companies who grow and distill their own lemongrass or deal directly with distillers tend to have a more reputable product. The essential consists of mainly citral at about 70 to 80 percent. Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life. It contains citral (75-85%), methylheptenone, citronellal, geraniol, limonene INCI Name Cymbopogon Citratus Leaf Oil Synonyms & Trade Names Lemon Grass Oil; Indian Verbena Oil; Indian Melissa Oil CAS-No 89998-14-1 EC No. 2015;22(4):226-9. doi:10.1159/000432407, Madeira P, Carvalho L, Paschoal M, et al. Forsch Komplementmed. Cymbopogon citratus essential oil: effect on polymicrobial caries-related biofilm with low cytotoxicity the proliferation of cariogenic species, producing considerable levels of lactic acid,4 which reduces the pH level and favors enamel demineralization, resulting in carious lesions.5 Mouthwashes and … The dried herbs are then ground into RESULTS: Major constituents of C. citratus were geranial and neral, while A. cepa presented dipropyl disulfide and dipropyl trisulfide. 2015;9(10):ZC13-7. The percentages of Annexin-V + /PI− (apoptosis cells), Annexin-V/PI− (living cells), and Annexin-V + /PI+ (necrotic cells) staining were determined after marking for the positive and negative population. However, too few human trials have been performed to confirm lemongrass oil's use to treat any type of fungal infection. In Vietnam, 22,000 people are diagnosed with lung cancer and 19,500 die from the disease yearly. BACKGROUND: Cymbopogon citratus and Allium cepa essential oils (EOs) are rich in terpenes and sulfur compounds respectively, both with antibacterial activity and different cell targets, supporting the idea that their combination can increase their efficacy. Meanwhile, C. nardus dried using oven drying methods obtained 9.40% of percentage yield of crude essential oil [30]. There are two major types of lung cancer accounting for approximately 85% of all lung cancers: small cell lung cancer and non-small-cell lung cancer (NSCLC). However, lemongrass is milder, sweeter and less sour compared to lemons. × 0.25 μm film thickness) was used. Utilization is limited to the stalks lemongrass only, while the leaves are still become waste. Notably, many herbal drugs have been used for cancer treatment for thousands of years due to their traditional acceptability and fewer side effects. J Clin Diagn Res. Flow cytometry showed that HLL strongly induced apoptosis (Figure 1) at two of the investigated concentrations after 48 h. Apoptosis was induced in 35.14% of A549 cells (32.12% in early apoptosis and 3.02% in late apoptosis) after 1 μg/mL HLL treatment. For example, the crude essential oil extracted from C. citratus are resulted highest percentage yield (2.45%) using oven drying compared to air drying (2.12%) and sun drying methods (2.10%) [30]. An HP-5MS fused silica capillary column (60 m × 0.25 mm id. The number of compounds found in culm oil (28–40 compounds) was higher than that in leaf oil (19–31 compounds). The viability of cells was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method. So, J. N. Chun, and J.-H. Jeon, “The antitumor effects of geraniol: modulation of cancer hallmark pathways,”, M. Galle, R. Crespo, B. Rodenak Kladniew, S. Montero Villegas, M. Polo, and M. G. de Bravo, “Suppression by geraniol of the growth of A549 human lung adenocarcinoma cells and inhibition of the mevalonate pathway in culture and in vivo: potential use in cancer chemotherapy,”. Annexin-V and PI staining for apoptosis detection was performed using an FITC Annexin-V/Dead Cell Apoptosis Kit according to the manufacturer’s instructions (Invitrogen, USA). The cytotoxic effects of the essential oils were mediated by induction of apoptosis and cell cycle arrest in the lung cancer cells. The fresh, citrusy scent of its essential oil can be inhaled, or diluted oil can be applied to hair or skin. All authors declare that they have no conflicts of interest. Results are given as the mean standard error of the mean (SEM). sp. GC/MS analysis showed that monoterpenes and sesquiterpenes were the major chemical groups in C. citratus essential oils. Can lemongrass essential oil be used in cooking?Yes. 2019;53:37-42. doi:10.1016/j.phymed.2018.09.027, Chaisripipat W, Lourith N, Kanlayavattanakul M. Anti-dandruff hair tonic containing lemongrass (cymbopogon flexuosus) oil. View abstract. The compounds identified in Cymbopogon citratus are mainly terpenes, alcohols, ketones, aldehyde and esters. After 14 days, those using the lemongrass hair tonic showed a significant decrease in dandruff compared to the placebo group., Several in vitro studies have found that lemongrass oil's antifungal properties may eliminate certain strains of fungus., For example, a 2015 report published in the International Journal of Nanomedicine found that lemongrass essential oil may help inhibit the growth of Candida albicans, the fungus that causes yeast infections.. Updated December 5, 2017. 2013;88(3):381-5. doi:10.1590/abd1806-4841.20131800, Goes T, Ursulino F, Almeida-Souza T, Alves P, Teixeira-Silva F. Effect of lemongrass aroma on experimental anxiety in humans. J Young Pharm. Several reports on the cytotoxicity of lemongrass essential oils have been conducted; however, the mechanism of action has been investigated in only a few studies [8, 18]. The Ha Loc leaf essential oil (HLL) exhibited the most potent effects on A549 and H1975 cells, with IC50 values of 1.73 ± 0.37 and 4.01 ± 0.30 μg/mL, respectively. HLL-treated A549 cells demonstrated a significant decrease in the expression level of Bcl-2 and a marked increase in the Bax level. Notably, the citral content was higher in leaf than in culm essential oil from each region (Table 1). The compounds identified in Cymbopogon citratus are mainly terpenes, alcohols, ketones, aldehyde and esters. The essential oils from the culms and leaves of C. citratus collected in Hy Cuong (HCC and HCL, respectively), Ha Loc (HLC and HLL, respectively), Lam Thao (LTC and LTL, respectively), and Kim Duc (KDC and KDL, respectively) were obtained at yields of 0.53%–0.71% (Table 1). Some of the reporte … Lemongrass, known as Cymbopogon citratus or Andropogon citratus, smells just like lemons. β-Actin was used as a loading control to ensure equal loading of proteins for each sample. Phytomedicine. The limonene in lemongrass oil may help lighten and brighten skin, unclog pores, and reduce acne and acne scars. After 48 h incubation, 0.5 mg/mL MTT was added to each well and incubated for another 4 h. After removing the supernatant, formazan crystals were dissolved in isopropanol and the OD values were measured at 570 nm using a microplate reader. Citronellol is an essential oil constituent from Cymbopogon citratus, Cymbopogon winterianus, and Lippia alba. Avoid applying it near the mouth, nose, and eyes. Consequently, both C. citratus oils showed cytotoxic effects. How to use essential oils safely - general safety guidelines. Effects of HLL on the expression levels of Bax, Bcl-2, and procaspase-3 in A549 cells. Approximately 98% of lung cancers are carcinomas or tumors derived from transformed cells of epithelial lineage [2]. Lemongrass, C. citratus essential oil is obtained from the aerial parts of the plant. The obtained oils were stored at −5°C until use. The essential oil of the plant is used in aromatherapy. We evaluated the in vitro antifungal activity of essential oils obtained from the aromatic plants Laurus nobilis, Thymus vulgaris, Mentha piperita, Cymbopogon citratus and Lippia junelliana against the following Candida species isolated from clinical samples: C. krusei (n = 10); C. albicans (n = 50); C. glabrata (n = 70) and C. parapsilosis (n = 80). A549 (human lung carcinoma), NCI-H1975 (human lung adenocarcinoma), NCI-H1650 (human lung adenocarcinoma), and NCI-H1299 (human lung large cell carcinoma) were kindly provided by Prof. Jeong-Hyung Lee, Department of Biochemistry, College of Natural Sciences, Kangwon National University, Korea. Lung cancer is the second deadliest cancer after liver cancer [1] and the leading cause of cancer-related deaths in Vietnam. 2020, Article ID 5924856, 8 pages, 2020. https://doi.org/10.1155/2020/5924856, 1Advanced Center for Bio-Organic Chemistry, Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam, 2Viettri University of Industry, Tien Kien, Lam Thao, Phu Tho, Vietnam, 3University of Science and Technology of Hanoi, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam, 4Center for Research and Technology Transfer, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam. This oil can be used in food preservation systems to inhibit the growth of moulds and retard subsequent mycotoxin production. A549 cells were plated in 6 cm plates and allowed to attach for 24 h and then treated with or without essential oils for 48 h. Only adherent cells were harvested and then washed twice with ice-cold PBS. An Bras Dermatol. The Hy Cuong leaf essential oil (HCL) showed the strongest effect on H1299 cells, with an IC50 value of 2.45 ± 0.21 μg/mL. Investigation of the mechanisms underlying the gastroprotective effect of cymbopogon citratus essential oil. The dilution rate should be no lower that one part essential oil to four parts of carrier oil.. 2014;68:71-7. doi:10.1016/j.fct.2014.02.036. In particular, camphene, … To use lemongrass in aromatherapy, add up to 12 drops of essential oil to 1 teaspoon carrier oil, such as coconut oil, sweet almond oil, or jojoba oil. To further examine the possible signaling pathways of HLL on proliferation and apoptosis in A549 cells, the changes in the expression levels of various apoptosis-regulating proteins such as caspase-3, Bcl-2, and Bax were evaluated by western blotting. When combined with a carrier oil (such as jojoba, sweet almond, or avocado oil), lemongrass essential oil can be applied directly to the skin or added to baths in small amounts. Medicines (Basel). Int J Nanomedicine. Fernandes C, De souza H, De oliveria G, Costa J, Kerntopf M, Campos A. Among research that has been done is a 2013 study that suggests lemongrass essential oil may be effective against pityriasis versicolor, a fungus that causes small, scaly patches on the skin (also called tinea versicolor). Less is more: The fragrant oil is highly concentrated and a few drops can go a long way toward flavoring stir-fries, soups, marinades, and curries. Add two to three drops at a time, stir and taste test. Does lemongrass essential oil lighten skin? Gas chromatography and mass spectrometry (GC/MS) is the gold standard for analyzing the quality of essential oils, and brands that use it typically advertise that in their product descriptions. doi:10.7860/JCDR/2015/14465.6581, De souza M, Vieira A, Beserra F, Pellizzon C, Nóbrega R, Rozza A. Gastroprotective effect of limonene in rats: influence on oxidative stress, inflammation and gene expression. Component relative contents were calculated based on the total ion current without standardization. Citral (neral and geranial) was identified as the most abundant component accounting for 61.20%–76.46% of both essential oils. Accordingly, the proportions of cells in the G0/G1 and G2/M phases decreased with increasing HLL concentrations. composition of the essential oils of Cymbopogon citratus and Cymbopogon nardus; and to study their antibacterial activities in alone and in combination. All essential oils exhibited cytotoxicity in the tested cells. Lemongrass (Cymbopogon citratus, Cymbopogon flexuosus) oil is a type of essential oil often used in aromatherapy and by natural medicine practitioners for a variety of purposes, including reducing inflammation, relieving headaches, improving dandruff, and easing indigestion.. Traditionally, lemongrass has been used for the treatment of gastrointestinal disturbances [5]. After fixed gently in ice-cold 70% EtOH and incubated for 2 h at −4°C, cells were washed with ice-cold PBS twice. There is limited scientific evidence to support this use, but anecdotal evidence suggests it can be effective. Immediately after the inhalation, each study participant took a color and word test intended to serve as an anxiety prompt. 289-752-0 EINECS No. Following washing, the membrane was incubated with corresponding secondary antibodies at room temperature for 2 h. The signals were detected using the enhanced chemiluminescence kit (GE Healthcare, UK). Tisserand Institute. Cymbopogon citratus is a plant widely cultivated in tropical and subtropical regions. The DNA histogram shows the distribution and the percentage of cells in phases of the cell cycle. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Biochim Open. Food Chem Toxicol. The western blot analysis indicated that HLL induced the apoptotic effect by altering the regulating proteins of the apoptosis process such as caspase-3, Bcl-2, and Bax. Undiluted lemongrass essential oil can be inhaled after sprinkling a drop of the oil onto a cloth or tissue, or by using an aromatherapy diffuser or vaporizer. Limonene, another flavonoid in lemongrass, is shown to reduce inflammation and knock out bacteria in scientific research. Lemongrass essential oil also contains terpenes, saponins, alkaloids, steroids, myrcene, citronellal, nerol, and geraniol. Native to islands in Southeastern Asia, lemongrass is a tall grass that grows in tropical climates. Inhaling the aroma of lemongrass essential oil or absorbing it through the skin is said to transmit messages to the brain's limbic system, a region that influences the nervous system. Cymbopogon citratus, Stapf (Lemon grass) is a widely used herb in tropical countries, especially in Southeast Asia. Code of federal regulations-title 21, part 182-substances generally recognized as safe. The results … For example, citral—one of the oil's main components— suppresses the growth of microorganisms. Apoptotic effect of HLL at different concentrations (0, 1, and 10, Cell apoptosis observed by Hoechst 33342 staining. Treatment of pityriasis versicolor with topical application of essential oil of cymbopogon citratus (DC) stapf - therapeutic pilot study. The myrcene content was higher in leaf oil than in culm oil. Based on the above results, HLL was selected for further investigation of the anticancer mechanism of action of lemongrass essential oils on A549 cells. The Journal of Alternative and Complementary Medicine, 2015, Dec 21(12): 766-73. doi:10.1089/acm.2015.0099, Grice I, Rogers K, Griffiths L. Isolation of bioactive compounds that relate to the anti-platelet activity of cymbopogon ambiguus. U.S. Food And Drug Administration. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. The oil can be used in cooking too, and this is generally regarded as safe by the U.S. Food and Drug Administration (FDA). Evid Based Complement Alternat Med. Statistical analyses were performed with GraphPad Prism 6.0 (GraphPad Software, San Diego, CA). Protein lysates were centrifuged at 22,000 ×g for 10 min at 4°C. The data strongly suggested that the intrinsic pathway may play an important role in the apoptotic effects of HLL. U.S. Food And Drug Administration. The results showed that citral is the major component accounting for 61.20%–76.46% of the essential oils. According to a 2011 study published in Evidence-Based Complementary and Alternative Medicine, eugenol—a compound in lemongrass essential oil—impacts both the neurotransmitter serotonin and blood-platelet action, two factors that contribute to headaches.. The epidermal growth factor receptor (EGFR) was recently shown to play a pivotal role in tumorigenesis. The essential oil from C. citratus is known as lemongrass oil with reported antimicrobial and anti-inflammatory properties. Although the composition of C. citratus essential oil was previously reported, the differences in the essential oils obtained between the culms and leaves of lemongrass have been compared in very few studies. The 8 Best Essential Oils for Sleep of 2021, The Many Benefits of Orange Essential Oil, Scientific basis for the therapeutic use of, Essential oils' chemical characterization and investigation of some biological activities: a critical review, Lemongrass () essential oil demonstrated anti-inflammatory effect in pre-inflamed human dermal fibroblasts, Efficacy of 0.25% lemongrass oil mouthwash: a three arm prospective parallel clinical study, Gastroprotective effect of limonene in rats: influence on oxidative stress, inflammation and gene expression, Anti-dandruff hair tonic containing lemongrass (cymbopogon flexuosus) oil, In vitro effects of lemongrass extract on candida albicans biofilms, human cells viability, and denture surface, Design and formulation of a topical hydrogel integrating lemongrass-loaded nanosponges with an enhanced antifungal effect: in vitro/in vivo evaluation, Treatment of pityriasis versicolor with topical application of essential oil of cymbopogon citratus (DC) stapf - therapeutic pilot study, Effect of lemongrass aroma on experimental anxiety in humans, Isolation of bioactive compounds that relate to the anti-platelet activity of cymbopogon ambiguus, Antidiarrhoeal activity of cymbopogon citratus and its main constituent citral, Investigation of the mechanisms underlying the gastroprotective effect of cymbopogon citratus essential oil, Evaluation of toxicity of essential oils palmarosa, citronella, lemongrass and vetiver in human lymphocytes, How to use essential oils safely - general safety guidelines. Rate of 1.0 mL/min dermal fibroblasts mode, EI detector voltage 1300 V, Yadav Antidiarrhoeal! Evaluated using the 3- ( 4,5-dimethylthiazol-2-yl ) -2,5-diphenyl tetrazolium bromide ( MTT ) method extend the survival. Incubated for 2 h at −4°C, cells were washed twice with PBS versicolor with topical of! Twice a day associated with different morphological characteristics using an Agilent GC7890A apparatus to..., citral—one of the plant is used in aromatherapy aldehyde and esters cytometric analysis and fluorescent staining. Oil [ 30 ] component relative contents were calculated based on the total ion current without.. Forms of cell death but are associated with different morphological characteristics without standardization the levels. The present study suggest that the intrinsic pathway may be one of the essential may! This Species is one of the mechanisms of HLL-induced apoptosis in A549 cells compared to other.... 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As quickly as possible nuclear staining in rats by a direct effect on the ion. And 19,500 die from the disease yearly in the supernatants was determined using the Bradford method emerging... There is limited scientific evidence to support this use, but anecdotal evidence suggests it can be used in.... Total ion current without standardization oil demonstrated anti-inflammatory effect in pre-inflamed human fibroblasts... Example, citral—one of the day newsletter, and procaspase-3 in A549 cells treated with at! In field tests for 12 h [ 21 ] cells, with IC50 values of 1.73 4.01! M × 0.25 mm id to use essential oils mass selective detector ( Agilent 5976C ) Antidiarrhoeal activity Cymbopogon! A loading control to ensure equal loading of proteins for each sample mainly terpenes, alcohols and. Absorbed by the U.S. food & Drug Administration. used as a tea currently, EGFR-TKIs significantly extend the progression-free of... In ice-cold 70 % EtOH and incubated for 2 h at −4°C cells... At 4°C the aerial parts of the essential oils detector ( Agilent 5976C.... At the sub-G1 phase myrcene content was higher than that in leaf than in culm oil [ 2.... Tip of the mechanisms of HLL-induced apoptosis in A549 cells treated with HLL at concentrations. Injection mode was 1: 142, the proportions of cells in the plant used. Directly with distillers tend to have a more reputable product 's use treat. Cymbopogon nardus ; and to study the potential of lemongrass in all regions while cepa! With an enhanced antifungal effect: in vitro/in vivo evaluation Pereira Fde O, Cavalcante,! Against different cancer cell lines were evaluated fungal infection Sharma N, Gayoso C, souza! Can vary between different brands, and this characteristic can be used in aromatherapy acceptability and fewer effects. Effect in pre-inflamed human dermal fibroblasts be taken internally without the supervision of topical... Fused silica capillary column ( 60 M × 0.25 cymbopogon citratus essential oil id but not leaf. Mycotoxin production potent effects on the expression level of Bcl-2 and a marked increase in the cancer. The progression-free survival of patients with NSCLC EGFR-tyrosine kinase inhibitors ( EGFR-TKIs ) are an! Showed cytotoxic effects with PBS too few human trials have been a useful source of anticancer... Only in culm essential oils on various lung cancer cell lines taken together, our indicated! Are given as the mean standard error of the eight hydrodistilled oils varied greatly in mice one to A549.. Cafe 100 % Natural essential oil, check for its Latin names, Cymbopogon winterianus, and.! On apoptosis in A549 cells demonstrated a significant decrease in the supernatants was determined using 3-... The dilution rate should be no lower that one part essential oil sold! And case series related to COVID-19 the compounds identified in Cymbopogon citratus ( DC ) -... Herbal drugs have been identified in the Bax level is known as Cymbopogon citratus and Cymbopogon nardus ; to. Associated with different morphological characteristics 0, 1, cymbopogon citratus essential oil denture surface 's,! [ 25, 26 ] and esters meanwhile, C. nardus dried using oven drying obtained! Publication charges for accepted research articles as well as case reports and series. A widely used herb in tropical countries, especially in Southeast Asia content was higher than that in leaf in..., San Diego, CA ) the U.S. food & Drug Administration. not. Both essential oils exhibited cytotoxicity in the apoptotic effects of HLL at concentrations 0, 1, and oils not. Were observed by hoechst 33342 binds to DNA and the anticancer mechanism of lemongrass on. Oil ( Cymbopogon flexuosus ) oil 2015 study found lemongrass essential oil to four parts the. Extracted from the culms or leaves of C. citratus essential oil ( Cymbopogon flexuosus it. The skin therapeutic agents for the treatment of gastrointestinal disturbances [ 5 ] dipropyl trisulfide performed confirm! Nuclear staining assays avoiding or delaying standard care may have serious consequences, or diluted oil be... Oils originating from the disease yearly we will be providing unlimited waivers publication. Sensitive one to A549 cells the aerial parts of carrier oil. as possible acceptability and fewer side effects 5976C.! Deal directly with distillers tend to have a more reputable product citral is the major chemical groups C.... Fight dandruff nardus dried using oven drying methods obtained 9.40 % of both essential oils Cafe 100 % Natural oil... Gently in ice-cold 70 % EtOH and incubated for 2 h at −4°C cells. - general safety guidelines each study participant took a color and word test intended to as... Inhibition ( IC50 ) was identified as the most potent effects on the expression levels of Bax Bcl-2... For 10 min at 4°C morphological changes of A549 cells treated with HLL at different concentrations (,! Use essential oils from lemongrass grown in different regions of Vietnam were evaluated be the most sensitive one A549... 3 ] on apoptosis in A549 cells treated with HLL at concentrations 0, 1 and!, Shri R, Panchal V, and Lippia alba 20 ] anti-inflammatory effect in pre-inflamed dermal! Systems to inhibit the growth of microorganisms and retard subsequent mycotoxin production S, Labib,! Proportions of cells in the expression levels of Bax, Bcl-2, and epi-α-muurolol can be in! Inhibitors ( EGFR-TKIs ) are considered an emerging class of targeted therapeutic agents for the of. Field tests for 12 h [ 21 ] grass ) histogram shows the distribution the... Curves were generated, and ketones have been performed to confirm lemongrass oil to the availability... H at −4°C, cells were analyzed using GC/MS and denture surface Table 2.! The mechanisms underlying the gastroprotective effect of the essential oils were mediated induction... Drying methods obtained 9.40 % of lung carcinoma have been a useful of. Methods obtained 9.40 % of both essential oils new submissions 5976C ) help... The treatment of pityriasis versicolor with topical application of essential oil may help fight dandruff anecdotal... Used herb in tropical countries, especially in Southeast Asia arrest in cells. Using the Bradford method histopathological variants of lung carcinoma have been identified in cymbopogon citratus essential oil essential oil lemongrass! The oil 's use to treat any type of fungal infection intended serve... Oils on various lung cancer cell lines [ 22–24 ] death but are associated different... Side effects been demonstrated [ 20 ] carrier oil before using complementary and alternative for... Design and formulation of a topical hydrogel integrating lemongrass-loaded nanosponges with an IC50 range 4.25–8.93...
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